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pentobarbital will minimize the level or influence of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers lowers plasma focus of abemaciclib and its metabolites.Pentobarbital could potentially cause drowsiness and impair mental and Bodily